Radiosurgery Practice Guideline Initiative Stereotactic Radiosurgery for Patients with Metastatic Brain Tumors

form. Local brain control was not defined in the abstract. In summary, three randomized trials detected an improvement in local brain control in patients treated with WBRT and radiosurgery boost compared with WBRT alone. Local brain control at one year ranged from 82–92% in the radiosurgery boost arm vs. 0–71% in the WBRT alone arm. The study by Kondziolka et al. also noted superior intracranial control with the use of radiosurgery. Aoyama et al. published the results of a prospective randomized trial of radiosurgery followed by WBRT versus radiosurgery alone. Local control rates with combined modality therapy were significantly better than with radiosurgery alone. The combination of the two therapeutic modalities provided a local control benefit similar to that seen in the combined modality arm of RTOG 95-08 (89% and 82%, respectively), demonstrating inter-study